Ethanol → Alanine, 2-methyl-, ethyl ester

Temperature

0 °C

2-Amino-2-methyl-propionic acid (1.0 g, 9.69 mmol) was dissolved in ethanol (15 ml) and cooled to 0° C. Thionyl chloride (1.7 g, 14.53 mmol, 1.5 eq) was added to the reaction mixture, which was then heated to reflux overnight. The solvent was evaporated and the residue was partitioned between water and ethyl acetate. The organic layer was concentrated and dried to give 2-amino-2-methyl-propionic acid ethyl ester (0.8 g, 63%). The crude compound was used in the next stage without purification.

1. temperaturewas then heated
2. temperatureto reflux overnight
3. customThe solvent was evaporated
4. customthe residue was partitioned between water and ethyl acetate
5. concentrationThe organic layer was concentrated
6. customdried

ORD record

ord-b9501f6ba7be4d5b99e63345d16d1dfc

Source dataset

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08486962B2