Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

HRID 450298

Reaction equation

HRID 450298 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH2:8]([CH2:12][C:13](=O)[CH3:14])[C:9]([CH3:11])=O.O>C1(C)C=CC=CC=1.CC(O)=O>[CH3:14][C:13]1[N:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:9]([CH3:11])=[CH:8][CH:12]=1

Participants

6

Reactant 3

HCID 962Water2×HCID 80352,5-HexanedioneHCID 1372541-Methyl-3-aminopyrazole

Product 1

HCID 132489953-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1140TolueneSolvent

Procedure

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

Workup

  1. temperatureheated
  2. concentrationConcentrated
  3. customto dry
  4. customThe residue is purified by flash column
  5. customto give product

Sources & evidence

ORD record
ord-c897f6aec06f4231b6a1c86ee56bc81c
Source dataset
uspto-grants-2013_07
Patent number
US08486954B2

Linked notes

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