HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynylcyclohexene → 1-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynylcyclohexene | HCID 79128 | — |
| Reactant | Toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester | HCID 29800848 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanone | HCID 25221607 | — |
Reaction Steps
This product was prepared from toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: DCM; yield (114 mg, 90%); 1H NMR δ (CDCl3): 7.53-7.41 (m, 3H), 6.29 (m, 1H), 3.92 (s, 3H), 2.51 (s, 3H), 2.31-2.12 (dm, 4H), 1.73-1.57 (m, 4H); LCMS m/z: 254.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08487109B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-dc315de689f544b883d3cae1f9f48485 |
| Source note | uspto-grants-2013_07 |