HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynylcyclohexene → 1-Cyclohex-1-enylethynyl-3-trifluoromethyl-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynylcyclohexene | HCID 79128 | — |
| Reactant | 1-(Tosyloxy)-3-(trifluoromethyl)benzene | HCID 11243986 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | 1-Cyclohex-1-enylethynyl-3-trifluoromethyl-benzene | HCID 11402444 | — |
Reaction Steps
This product was prepared from toluene-4-sulfonic acid 3-trifluoromethyl-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane; yield (106 mg, 85%); 1H NMR δ (CDCl3): 7.68 (s, 1H), 7.6-7.7.49 (m, 2H), 7.46-7.37 (m, 1H), 6.28 (m, 1H), 2.31-2.12 (m, 4H), 1.73-1.57 (m, 4H); LCMS m/z: 250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08487109B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-21e22cb1250f455d80a40c26aef66b6b |
| Source note | uspto-grants-2013_07 |