Methylhydrazine → HCID 59394553, compound
Reaction equation
[CH3:1][C:2]1([C:5](=O)[CH2:6][C:7]#[N:8])[CH2:4][CH2:3]1.[CH3:10][NH:11][NH2:12]>CO>[CH3:10][N:11]1[C:7]([NH2:8])=[CH:6][C:5]([C:2]2([CH3:1])[CH2:4][CH2:3]2)=[N:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-(1-methyl-cyclopropyl)-3-oxo-propionitrile (1.0 g, 8.1 mmol), methylhydrazine (0.56 g, 12.2 mmol) and MeOH (40 mL) is heated at 80° C. for 16 h. The solution is then concentrated in vacuo and the residue is suspended in 5 mL DCM and 20 mL heptane, filtered to give product. MS (ESI) m/z 152.3 (M+1).
Workup
- concentrationThe solution is then concentrated in vacuo
- filtration20 mL heptane, filtered
- customto give product
Sources & evidence
- ORD record
- ord-038b0dc6e35f47558d5017f14f54a917
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541432B2
Reaction notes
Loading…