3-(3-Fluorophenyl)propionic acid → Tert-butyl [4-[[2-[3-(3-fluorophenyl)propanoyl]hydrazino]carbonyl]-2-pyridyl]carbamate

HRID 452616

Reaction equation

HRID 452616 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][CH:7]=1.[C:13]([O:17][C:18](=[O:30])[NH:19][C:20]1[CH:25]=[C:24]([C:26]([NH:28][NH2:29])=[O:27])[CH:23]=[CH:22][N:21]=1)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18](=[O:30])[NH:19][C:20]1[CH:25]=[C:24]([C:26]([NH:28][NH:29][C:10](=[O:12])[CH2:9][CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)=[O:27])[CH:23]=[CH:22][N:21]=1)([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 27374893-(3-Fluorophenyl)propionic acidHCID 86640026Tert-butyl [4-(hydrazinocarbonyl)-2-pyridyl]carbamate

Product 1

HCID 86640025Tert-butyl [4-[[2-[3-(3-fluorophenyl)propanoyl]hydrazino]carbonyl]-2-pyridyl]carbamateYield 60%

Procedure

In the same manner as in Reference Example 1 and using 3-(3-fluorophenyl)propionic acid instead of benzothiazole-6-carboxylic acid and tert-butyl[4-(hydrazinocarbonyl)-2-pyridyl]carbamate instead of tert-butyl carbazate, the title compound (yield 60%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-2c88286c69ad48efb8394d62cacbe8aa
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Linked notes

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