2-Acetoxypropionic Acid → 1-Methyl-2-oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetate

HRID 452654

Reaction equation

HRID 452654 reaction equation
[C:1]([O:4][CH:5]([CH3:9])[C:6]([OH:8])=O)(=[O:3])[CH3:2].[F:10][C:11]([F:33])([F:32])[O:12][C:13]1[CH:14]=[C:15]([C:19]2[C:23]3[CH:24]=[C:25]([C:28]([NH:30][NH2:31])=[O:29])[CH:26]=[CH:27][C:22]=3[O:21][CH:20]=2)[CH:16]=[CH:17][CH:18]=1>>[C:1]([O:4][CH:5]([CH3:9])[C:6](=[O:8])[NH:31][NH:30][C:28]([C:25]1[CH:26]=[CH:27][C:22]2[O:21][CH:20]=[C:19]([C:15]3[CH:16]=[CH:17][CH:18]=[C:13]([O:12][C:11]([F:10])([F:32])[F:33])[CH:14]=3)[C:23]=2[CH:24]=1)=[O:29])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 790412-Acetoxypropionic AcidHCID 686643883-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide

Product 1

HCID 686641251-Methyl-2-oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetateYield 48%

Procedure

In the same manner as in Reference Example 1 and using (±)-2-acetoxypropionic acid instead of benzothiazole-6-carboxylic acid and 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide instead of tert-butyl carbazate, the title compound (yield 48%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-465c29856ff445689dbe99214503ebe4
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Linked notes

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