4-Methoxyphenylacetic Acid → 2-(1-Benzofuran-5-yl)-5-(4-methoxybenzyl)-1,3,4-oxadiazole

HRID 452716

Reaction equation

HRID 452716 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=[O:11])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](O)=O)=[CH:18][CH:17]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:23]([CH2:22][C:19]4[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=4)=[N:13][N:12]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 686641291-Benzofuran-5-carbohydrazide

Product 1

HCID 686643812-(1-Benzofuran-5-yl)-5-(4-methoxybenzyl)-1,3,4-oxadiazoleYield 58%

Procedure

In the same manner as in Example 14 and using 1-benzofuran-5-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and (4-methoxyphenyl)acetic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 58%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-d1189b61505944b29e8199ac7292bc5a
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Linked notes

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