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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452744Generated: October 27, 2026

3-(3-Trifluoromethylphenyl)propanoic acid → 1-(4-methoxyphenyl)-6-[5-[2-[3-(trifluoromethyl)phenyl]ethyl]-1,3,4-oxadiazol-2-yl]-1H-benzimidazole

https://huagongshe.com/reaction/452744

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3-Trifluoromethylphenyl)propanoic acidHCID 2777683—
Reactant1-(4-methoxyphenyl)-1H-benzimidazole-6-carbohydrazideHCID 68663377—
Product1-(4-methoxyphenyl)-6-[5-[2-[3-(trifluoromethyl)phenyl]ethyl]-1,3,4-oxadiazol-2-yl]-1H-benzimidazoleHCID 6866411150%

Reaction Steps

In the same manner as in Example 14 and using 1-(4-methoxyphenyl)-1H-benzimidazole-6-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 3-[3-(trifluoromethyl)phenyl]propionic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 50%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-9a80d29e81504d94a8436e0ca75bc670
Source noteuspto-grants-2013_07