Acetic Acid → HCID 178476642, compound

HRID 45298

Reaction equation

HRID 45298 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[C:11]([OH:14])(=[O:13])[CH3:12].[OH-].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:11]([O-:14])(=[O:13])[CH3:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Product 1

HCID 178476642HCID 178476642, compoundYield 52.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

1 Kg (1 equivalent) of metformin hydrochloride and 2 L of water, and then 0.5 L (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 289.8 g (1.2 equivalents) of aqueous solution of sodium hydroxide were added to the reaction solution for 1 hour. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 601 g of metformin acetate (yield: 52.7%).

Workup

  1. dissolutionto dissolve thoroughly
  2. filtrationThe resulting crystal was filtered
  3. washwashed with acetone
  4. customdried at 60° C.

Sources & evidence

ORD record
ord-454cebb606194248a921a8f6ef541f6e
Source dataset
uspto-grants-2013_09
Patent number
US08541474B2

Linked notes

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