Acetic Acid → HCID 178476642, compound
Reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[C:11]([OH:14])(=[O:13])[CH3:12].[OH-].[K+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:11]([O-:14])(=[O:13])[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
20.0 g (1 equivalent) of metformin hydrochloride and 50 Ml of water, and then 10 Ml (1.45 equivalents) of glacial acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 10.2 g (1.5 equivalents) of aqueous solution of potassium hydroxide were added to the reaction solution. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 13.3 g of metformin acetate (yield: 58.2%).
Workup
- dissolutionto dissolve thoroughly
- filtrationThe resulting crystal was filtered
- washwashed with acetone
- customdried at 60° C.
Sources & evidence
- ORD record
- ord-ead53a2a910145fe98b79b14158b2a53
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541474B2
Reaction notes
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