HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 2-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | 2-Amino-4-methyl-thiazole-5-carboxylic acid | HCID 832243 | — |
| Product | 2-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide | HCID 62793398 | 15% |
Reaction Steps
Following the procedure as described in Preparation 1, making variation only as required to use 4-chlorobenzylamine to replace benzylamine to react with 2-amino-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a white solid in 15% yield; 1H NMR (CD3OD, 300 MHz) δ 7.26-7.32 (m, 4H), 4.41 (s, 2H), 2.38 (s, 3H). MS (ES+) m/z 282.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541457B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-71a0d48e151b4f408c37694c52a3b666 |
| Source note | uspto-grants-2013_09 |