N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acid → 4-Methyl-2-[(2-phenylcyclopropanecarbonyl)amino]thiazole-5-carboxylic Acid Benzylamide

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations only as required to use 2-phenylcyclopropanecarbonyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 73% yield; 1H NMR (DMSO-d6, 300 MHz) δ 7.38-7.03 (m, 10H), 5.87 (s, br, 1H), 4.56-4.50 (m, 2H), 2.70-2.63 (m, 1H), 2.41 (s, 3H), 1.81-1.73 (m, 2H), 1.52-1.23 (m, 1H); MS (ES+) m/z 391.8 (M+1).

Provenance & Evidence