HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 4-(2,3-Epoxypropoxy)salicylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2,4-Dihydroxybenzoate | HCID 16523 | — |
| Product | 4-(2,3-Epoxypropoxy)salicylic acid methyl ester | HCID 12611335 | — |
Reaction Steps
By refluxing 34 g of 2,4-dihydroxybenzoic acid methyl ester with 185 g of epichlorohydrin and 35 g of potassium carbonate for 2 to 3 hours, and chromatographing the crude product on 100 g of silica gel (elution with toluene), 4-(2,3-epoxypropoxy)salicylic acid methyl ester having a melting point of 53°-55° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04727067 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-04f489d6f4b84e0caced2494d503c25d |
| Source note | uspto-grants-1988_02 |