Dimethylamine methanol → HCID 46947729, compound

HRID 454817

Reaction equation

HRID 454817 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1.CO.[CH3:24][NH:25][CH3:26]>>[CH3:24][N:25]([C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1)[CH3:26]

Participants

3

Reactant 2

HCID 22497844Dimethylamine methanolHCID 866465572-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene

Product 1

HCID 46947729HCID 46947729, compoundYield 70%

Procedure

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-39, 50 mg, 70%) was prepared in the same manner as in Example 36 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoro propoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.17 mL, 0.34 mmol).

Workup

  1. customobtained in Preparation Example 21

Sources & evidence

ORD record
ord-88bf5b9b36a1453f9c4fe1d63f7373aa
Source dataset
uspto-grants-2013_07
Patent number
US08497260B2

Linked notes

Loading…