3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-methylpyrimidin-2(1H)-one

HRID 455055

Reaction equation

HRID 455055 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[CH3:20][C:21]1[CH:26]=[CH:25][NH:24][C:23](=[O:27])[N:22]=1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]3[C:4]=2[CH2:3][N:24]2[CH:25]=[CH:26][C:21]([CH3:20])=[N:22][C:23]2=[O:27])=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochlorideHCID 178428670HCID 178428670, compoundHCID 1784286934-Methylpyrimidin-2-ol hydrochloride

Product 1

HCID 583368841-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-methylpyrimidin-2(1H)-one

Procedure

The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4-methylpyrimidin-2(1H)-one or 4-methylpyrimidin-2-ol. m/e+ 351 for C19H16ClN40 (M+H)+.

Sources & evidence

ORD record
ord-7b91e65bd41c4180a381606d9c8612ef
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Linked notes

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