2-Amino-4,6-difluoropyrimidine → 4,6-difluoro-N-((2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine

HRID 455089

Reaction equation

HRID 455089 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[F:19][C:20]1[CH:25]=[C:24]([F:26])[N:23]=[C:22]([NH2:27])[N:21]=1>>[F:19][C:20]1[CH:25]=[C:24]([F:26])[N:23]=[C:22]([NH:27][CH2:3][C:4]2[N:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]3=[N:6][C:5]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:21]=1

Participants

3

Reactant 2

HCID 12014802-Amino-4,6-difluoropyrimidineHCID 670287853-(Chloromethyl)-2-phenylimidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 670290824,6-difluoro-N-((2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amineYield 17%

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-2-phenylimidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. (0.10 g, 17% yield), M/e− 338.2 for C18H13F2N5 (M+H)+

Sources & evidence

ORD record
ord-16f9e0327caf4022bd770cac06923ce3
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Linked notes

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