2-(Methylamino)ethanol → 2-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol

Participants

Role	Name	HCID	Charge
Reactant	2-(Methylamino)ethanol	HCID 8016	—
Reactant	1-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-ol	HCID 67029099	—
Reactant	2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine	HCID 86655124	—
Product	2-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol	HCID 67027542	—

Reaction Steps

The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and 2-(methylamino)ethanol. M/e+ 394 for C21H21ClN5O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.06 (d, J=6.6 Hz, 1H), 7.89 (s, 1H), 7.78 (d, J=8.4 Hz, 2H), 7.70 (s, 1H), 7.60 (dd, J=8.4, 0.7 Hz, 1H), 7.40 (d, J=8.4 Hz, 2H), 7.17 (m, 1H), 6.77 (t, J=6.9 Hz, 1H), 4.34 (s, 2H), 3.64 (t, J=5.1 Hz, 2H), 3.54 (t, J=5.1 Hz, 2H), 3.05 (s, 3H) ppm.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-a2851c04125e4ac689ea2699e2d956c6
Source note	uspto-grants-2013_07