4'-Chloro-4-biphenylol → HCID 67392249, compound

HRID 456024

Reaction equation

[C:1]([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=[O:19])[CH2:17]Cl)[N:15]=1)([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1>>[C:1]([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=[O:19])[CH2:17][O:34][C:31]2[CH:30]=[CH:29][C:28]([C:25]3[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][CH:24]=3)=[CH:33][CH:32]=2)[N:15]=1)([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 915894'-Chloro-4-biphenylol

HCID 58451403HCID 58451403, compound

Product 1

HCID 67392249HCID 67392249, compoundYield 45.4%

Procedure

By an operation similar to that in Example 2-1 and using 2-{[4-(chloroacetyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (1.49 g) obtained in Example 1 and 4′-chlorobiphenyl-4-ol (772 mg), 2-[(4-{[(4′-chlorobiphenyl-4-yl)oxy]acetyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (864 mg) was obtained. By successive operations similar to those in Example 2-2 and 2-3 using 568 mg thereof, the title compound (299 mg) was obtained.

Sources & evidence

ORD record: ord-c015f3f7e62a4fbaa7c83f700a3cd11d
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08497382B2

Linked notes

Loading…