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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456229Generated: October 27, 2026

2-Bromo-5-(trifluoromethyl)benzyl alcohol → (2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

https://huagongshe.com/reaction/456229

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-(trifluoromethyl)benzyl alcoholHCID 2756248—
ReactantMethyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 57576289—
Product(2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl esterHCID 66606415—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester and 2-bromo-5-(trifluoromethyl)benzyl alcohol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497381B2
Source datasetuspto-grants-2013_07
ORD IDord-0d07d0700d8247199a0839f28ef1170e
Source noteuspto-grants-2013_07