2-Bromo-5-(trifluoromethyl)benzaldehyde → HCID 86633169, compound

HRID 456241

Reaction equation

HRID 456241 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][O:15][C:16](=[O:34])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[C:20](B2OC(C)(C)C(C)(C)O2)[CH:19]=1>>[CH3:14][O:15][C:16](=[O:34])[CH2:17][C:18]1[CH:19]=[C:20]([C:2]2[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=2[CH:4]=[O:5])[C:21]([F:24])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehydeHCID 46739456Methyl [4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

Product 1

HCID 86633169HCID 86633169, compound

Procedure

Prepared according to the procedure described in Example 25, Step 3, using the following starting materials: 2-bromo-5-trifluoromethyl-benzaldehyde and [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester; the isolated product was further purified by preparative HPLC.

Workup

  1. customPrepared
  2. customthe isolated product was further purified by preparative HPLC

Sources & evidence

ORD record
ord-914b9f35f9da455596557ffce904cd50
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Linked notes

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