3-Piperidinol, 1-methyl- → 4-[2-(1-Methyl-piperidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 456441

Reaction equation

HRID 456441 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27]OC[CH2:24]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29](OC(N1CCN(C2C=CC=CC=2O)CC1)=O)(C)(C)C.CN1CCCC(O)C1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH:21]2[CH2:29][CH2:27][CH2:28][N:23]([CH3:24])[CH2:22]2)[CH2:10][CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 980163-Piperidinol, 1-methyl-HCID 11543684Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylateHCID 184367644-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 694172234-[2-(1-Methyl-piperidin-3-yloxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared in a manner similar to 4-[2(2-Morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-carboxylicacid tert-butyl ester except that 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester was coupled to 1-methyl-piperidin-3-ol.

Sources & evidence

ORD record
ord-018fbdc1147f474b85b3273ed44ec37e
Source dataset
uspto-grants-2007_03
Patent number
US07186715B2

Linked notes

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