HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester → Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester | HCID 11247158 | — |
| Catalyst | Palladiumcarbon | HCID 14818447 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide | HCID 11231497 | 59% |
Reaction Steps
A solution of (e) (6.0 g, 14.3 mmol) in ethanol/ethyl acetate (150 ml/150 ml) was hydrogenated over 10% Pd/charcoal (5 g) for 1.5 hours. Filtration, washing with ethanol (400 ml) and evaporation of the filtrate gave a white solid (2.4 g, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186730B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-62de4b780e9d4801979ff0c701b6f06c |
| Source note | uspto-grants-2007_03 |