Thiourea → 2,4,6-Trimethyloxan-4-amine
Reaction equation
ClCC([NH:5][C:6]1([CH3:14])[CH2:11][CH:10]([CH3:12])[O:9][CH:8]([CH3:13])[CH2:7]1)=O.NC(N)=S>C(O)C.C(O)(=O)C>[CH3:13][CH:8]1[CH2:7][C:6]([NH2:5])([CH3:14])[CH2:11][CH:10]([CH3:12])[O:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-chloro-N-(2,4,6-trimethyltetrahydro-2H-pyran-4-yl) acetamide obtained in Example 9-3 (1.85 g) in ethanol/acetic acid (5/1, 15 mL), was added thiourea (705 mg) at room temperature. The reaction mixture was heated at reflux for 2 hrs.
Workup
- temperatureThe reaction mixture was heated
- temperatureat reflux for 2 hrs
Sources & evidence
- ORD record
- ord-0406e3b2854449c3adf315cb5c868ee7
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07186731B2
Reaction notes
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