Bromine → 3-Bromo-1,1-dimethoxypropan-2-one

HRID 457393

Reaction equation

HRID 457393 reaction equation
[Br:1]Br.[CH3:3][O:4][CH:5]([O:9][CH3:10])[C:6](=[O:8])[CH3:7]>CO>[Br:1][CH2:7][C:6](=[O:8])[CH:5]([O:9][CH3:10])[O:4][CH3:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 80650Pyruvic aldehyde dimethyl acetal

Product 1

HCID 120035673-Bromo-1,1-dimethoxypropan-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Bromine (80 g, 0.5 mol) is added dropwise to a solution of 1,1-dimethoxy-propan-2-one 205 (59 g, 0.5 mol) in anhydrous methanol (400 mL) at 0° C. and the solution is continued stirring at room temperature for 48 h. The solvent is removed under reduced pressure and the residue is dried in vacuo and used without further purification.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customthe residue is dried in vacuo
  3. customused without further purification

Sources & evidence

ORD record
ord-189330a0d2cb478a9470be0fe0c6286d
Source dataset
uspto-grants-2007_03
Patent number
US07186734B2

Linked notes

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