3-(4-Methoxyphenyl)propylazide → 3-(4-Methoxyphenyl)propan-1-amine

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][N:12]=[N+]=[N-])=[CH:5][CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][NH2:12])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 117153263-(4-Methoxyphenyl)propylazide

HCID 21226445Aluminium lithium hydride

Product 1

HCID 30298153-(4-Methoxyphenyl)propan-1-amine

Procedure

Amine 13 was prepared as described in procedure A from azide 12 (5.2 g, 0.027 mol) and LAH (26 ml of 1 M solution in THF).

Sources & evidence

ORD record: ord-f71c8b427f61460eb3b2c36669063f2b
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192958B2

Reaction notes

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