2-Hydroxyfluoren-9-one → (2S)-2-Methoxy-3-{4-[3-(9-oxo-9H-fluoren-2-yloxy)-prop-1-ynyl]-phenyl}-propionic acid

HRID 459079

Reaction equation

HRID 459079 reaction equation
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[OH:20][C:21]1[CH:33]=[CH:32][C:31]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24](=[O:34])[C:23]=2[CH:22]=1>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][O:20][C:21]2[CH:33]=[CH:32][C:31]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[C:24](=[O:34])[C:23]=3[CH:22]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

Participants

3

Reactant 2

HCID 813862-Hydroxyfluoren-9-oneHCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 10136381(2S)-2-Methoxy-3-{4-[3-(9-oxo-9H-fluoren-2-yloxy)-prop-1-ynyl]-phenyl}-propionic acid

Procedure

The title compound was prepared from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5 Step A and 2-hydroxy-9-fluorenone in a manner analogous to that described for Example 5, Step B. MS(ES) for C26H20O5 [M−H]−: 411.2

Sources & evidence

ORD record
ord-fbfc4fff721f4fa08caf4dd85b3bfe73
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Linked notes

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