4-(3-Bromopropoxy)1-phenoxybenzene → (2S)-3-{3-Allyl-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH2:14][CH:15]=[CH2:16])[CH:8]=1)[CH3:2].Br[CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:27][CH:26]=1>>[CH2:1]([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:21][CH2:22][CH2:23][O:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:27][CH:26]=2)=[C:9]([CH2:14][CH:15]=[CH2:16])[CH:8]=1)[CH3:2]Participants
3
Procedure
(2S)-3-(3-Allyl-4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester from Step A was allowed to react with 4-(3-bromopropoxy)-1-phenoxybenzene under the Standard Procedure I to give the title compound.
Sources & evidence
- ORD record
- ord-9cfed5cbad4c4dc798add200bef16905
- Source dataset
- uspto-grants-2007_03