Benzylamine → HCID 178420324, compound

Participants

Reaction Steps

The compound was synthesized starting from 5-bromobenzimidazole (200 mg; 1 mmol; 1 eq.), benzylamine (128 mg; 0.127 ml; 1.2 mmol; 1.2 eq.), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (9 mg; 0.024 mmol; 0.024 eq.; 2.4 mol %), Pd2 dba3 (9 mg; 0.01 mmol; 0.01 eq.; 1 mol %) and lithiumbis(trimethylsilyl)amide 1 M in THF (2.2 ml; 2.2 mmol; 2.2 eq.) according to method 1; Yield: 0.150 g (67.3%); MS m/z: 224.5 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.33 (s, 2H); 6.64 (d, 1H, 4J=2.1 Hz); 6.98 (dd, 1H; 4J=2.1 Hz, 3J=8.9 Hz); 7.23-7.38 (m, 5H); 7.51 (d, 1H, 3J=8.9 Hz); 8.07 (s, 1H); HPLC (METHOD [A]): rt 22.19 min (80.6%)

Provenance & Evidence