HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminobenzimidazole → N-(4-Methoxybenzyl)-3H-benzo[d]imidazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminobenzimidazole | HCID 13623 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Product | N-(4-Methoxybenzyl)-3H-benzo[d]imidazol-5-amine | HCID 53496067 | — |
Reaction Steps
Alternatively the compound was synthesized starting from benzimidazol-5-amine (2.66 g; 20 mmol; 1 eq.), 4-methoxybenzaldehyde (3.26 g; 2.9 ml; 24 mmol; 1.2 eq.), NaBH4 (1.14 g; 30 mmol; 1.5 eq.) and 5 N NaOH (20 ml; 100 mmol; 5 eq.) according to method 2; Yield: 4.53 g (89.5%); MS m/z: 254.3 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541596B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-ee3de9ca086b48009106c748d999d6cc |
| Source note | uspto-grants-2013_09 |