Sodium Hydroxide → (2S)-4'-{3-[4-(2-Carboxy-2-methoxy-ethyl)-2-methoxy-phenoxy]-propoxy}-biphenyl-4-carboxylic acid

HRID 459278

Reaction equation

C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([CH2:28][C@H:29]([O:34][CH3:35])[C:30]([O:32]C)=[O:31])=[CH:24][C:23]=3[O:36][CH3:37])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].CO[2H]>>[C:30]([C@@H:29]([O:34][CH3:35])[CH2:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][CH2:20][CH2:19][CH2:18][O:17][C:14]2[CH:13]=[CH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=3)=[CH:16][CH:15]=2)=[C:23]([O:36][CH3:37])[CH:24]=1)([OH:32])=[O:31]

Participants

Reactant 3

HCID 14798Sodium Hydroxide

HCID 123113Methan(2H)ol

HCID 58822569(2S)-4'-{3-[2-Methoxy-4-(2-methoxy-2-methoxycarbonyl-ethyl)-phenoxy]-propoxy}-biphenyl-4-carboxylic acid methyl ester

Product 1

HCID 58822805(2S)-4'-{3-[4-(2-Carboxy-2-methoxy-ethyl)-2-methoxy-phenoxy]-propoxy}-biphenyl-4-carboxylic acid

Procedure

The title compound was prepared from 4′-{3-[2-methoxy-4-(2-methoxy-2-methoxycarbonyl-ethyl)-phenoxy]-propoxy}-biphenyl-4-carboxylic acid methyl ester (Step B) by standard hydrolysis procedure C (NaOH). 1H-NMR (MeOD, 300.15 MHz):

Sources & evidence

ORD record: ord-7f44fe3c8ae64e36bc7bbf46fdf91b87
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Linked notes

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