HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazinamide → Isoniazid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazinamide | HCID 1046 | — |
| Reactant | (+)-Lactose | HCID 440995 | — |
| Reactant | (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochloride | HCID 16051971 | — |
| Reactant | Rifampicin | HCID 135398735 | — |
| Solvent | Water | HCID 962 | — |
| Product | Isoniazid | HCID 3767 | — |
Reaction Steps
Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07195769B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-5e15d77afc0e48bba66338ba929a252c |
| Source note | uspto-grants-2007_03 |