Pyrazinamide → Isoniazid

HRID 459739

Reaction equation

HRID 459739 reaction equation
N1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](N)=O.CC[C@H](NCCN[C@H]([CH2:22][OH:23])CC)CO.Cl.CC1C2O[C@]3(C)OC=C[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)C=CC=C(C)C(NC4C(/C=[N:61]/[N:62]5CCN(C)CC5)=C(O)C(C=2C3=O)=C(C=4O)C=1O)=O.OC1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O>O>[CH:6]1[C:7]([C:22]([NH:61][NH2:62])=[O:23])=[CH:2][CH:3]=[N:4][CH:5]=1

Participants

6

Reactant 4

HCID 1046PyrazinamideHCID 440995(+)-LactoseHCID 16051971(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochlorideHCID 135398735Rifampicin

Product 1

HCID 3767Isoniazid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.

Workup

  1. customPass the wet mass through multimill and dry the granules at 50–60° C
  2. customPass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60
  3. additionmix with dried granules and isoniazid delayed release powder

Sources & evidence

ORD record
ord-5e15d77afc0e48bba66338ba929a252c
Source dataset
uspto-grants-2007_03
Patent number
US07195769B2

Linked notes

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