HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N-Benzylaminodiacetic acid | HCID 77606 | — |
| Reactant | 5-Aminoindole | HCID 78867 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione | HCID 22931025 | — |
Reaction Steps
N-Benzyliminodiacetic acid was reacted with CDI and 5-aminoindole in THF to obtain 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione, which was then reacted with lithium aluminum hydride in THF. Conc. hydrochloric acid and palladium hydroxide were added to an ethanol solution of thus obtained compound and the whole was reacted under a hydrogen atmosphere of 3 atm for 65 hours to obtain an objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196080B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-b6dd4d4e1f0746f5a86b715e167a3784 |
| Source note | uspto-grants-2007_03 |