HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459925Generated: October 27, 2026
Acetyl chloride → 4-(Piperidin-4-yloxy)benzonitrile hydrochloride
https://huagongshe.com/reaction/459925
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate | HCID 23019443 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Piperidin-4-yloxy)benzonitrile hydrochloride | HCID 17832273 | 96% |
Reaction Steps
Add dropwise acetyl chloride (2.5 mL) to methanol (5.0 mL) at 0° C. Stir the resulting solution at 0° C. for 90 min. Then add a solution of 4-(4-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (284 mg, 0.94 mmol) in methanol. Stir the resulting mixture for 3 h. Evaporate the solvent and triturate with diethyl ether to provide the title compound (216 mg, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07196100B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-494f68581f2d484bbc465e010094f0fe |
|---|
| Source note | uspto-grants-2007_03 |
|---|
