Borohydride → 4-Methoxy-3-(4-methoxyphenyl)benzyl alcohol

HRID 460136

Reaction equation

HRID 460136 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[BH4-]>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 28123BorohydrideHCID 223911916,4'-Dimethoxybiphenyl-3-carbaldehyde

Product 1

HCID 688416394-Methoxy-3-(4-methoxyphenyl)benzyl alcoholYield 87.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-methoxy-3-(4-methoxyphenyl)benzenecarboxaldehyde (1 g, 4.13 mmol) in methanol (12 mL) was treated with polymer-supported borohydride (10.3 mmol) and the mixture shaken for 16 hours. The resin was then filtered and the filtrate concentrated under reduced pressure to afford 0.88 g of title compound.

Workup

  1. filtrationThe resin was then filtered
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-a9f128eb66ba4a03a994df7c3c66eb4c
Source dataset
uspto-grants-2007_03
Patent number
US07196102B2

Linked notes

Loading…