Ethyl 1-bromocyclobutanecarboxylate → 6-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-one

HRID 46047

Reaction equation

HRID 46047 reaction equation
[CH3:1][C:2]1([CH3:11])[C:4]([CH3:6])([CH3:5])[CH:3]1[NH:7][C:8]([NH2:10])=[S:9].Br[C:13]1([C:17](OCC)=[O:18])[CH2:16][CH2:15][CH2:14]1>>[CH3:1][C:2]1([CH3:11])[C:4]([CH3:5])([CH3:6])[CH:3]1[NH:7][C:8]1[S:9][C:13]2([C:17](=[O:18])[N:10]=1)[CH2:16][CH2:15][CH2:14]2

Participants

3

Reactant 2

HCID 97595Ethyl 1-bromocyclobutanecarboxylateHCID 79006986N-(2,2,3,3-tetramethylcyclopropyl)thiourea

Product 1

HCID 1784283516-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-one

Procedure

Synthesis was performed from N-(2,2,3,3-tetramethylcyclopropyl)thiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-064c10a8730a4507b8c96360c606469f
Source dataset
uspto-grants-2013_09
Patent number
US08541592B2

Linked notes

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