HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| Reactant | 3-Bromo-4-chlorobenzylhydrazine | HCID 23334355 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one | HCID 20367315 | — |
Reaction Steps
49 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid were dissolved in 225 ml of ethanol and 72 g of 3 -bromo-4-chlorobenzylhydrazine were added under nitrogen. After standing overnight, the compound identified above had settled out as a precipitate and was filtered off and recrystallised twice from ethanol. Melting point: 171°-172° C, 40 g (43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061653 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-dc2f9e3c43324419b09926dd65c45197 |
| Source note | uspto-grants-1977_12 |