HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarbothioamide | HCID 13402923 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide | HCID 13657336 | — |
Reaction Steps
1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04727081 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-fc8d952f1485405099b4c829a6ef36c1 |
| Source note | uspto-grants-1988_02 |