[6-(Hydroxymethyl)pyridin-3-yl]methanol → 5-(Hydroxymethyl)pyridine-2-carboxaldehyde

HRID 461077

Reaction equation

HRID 461077 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][N:4]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][N:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 820251[6-(Hydroxymethyl)pyridin-3-yl]methanol

Product 1

HCID 135185625-(Hydroxymethyl)pyridine-2-carboxaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

2,5-Di(hydroxymethyl)pyridine (10 g.) in 300 ml. of hot chloroform is treated with 100 g. of manganese dioxide. After 1/2 hour of stirring, the mixture is filtered and the filtrate is evaporated to dryness to give 2-formyl-5-hydroxymethylpyridine.

Workup

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-710d4b0f86874e83a8868df86c633f3f
Source dataset
uspto-grants-1977_12
Patent number
US04061759

Linked notes

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