Bromo-4'-chloro-3'-sulfamoylacetophenone → 3-Ethyl-4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461119

Reaction equation

HRID 461119 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:18][C:19]([NH:21][CH:22]([CH3:24])[CH3:23])=[S:20])[CH3:17]>CC(C)=O>[ClH:11].[CH2:16]([N:18]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:20][C:19]1=[N:21][CH:22]([CH3:24])[CH3:23])[CH3:17]

Participants

4

Reactant 2

HCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenoneHCID 196505951-Ethyl-3-isopropylthiourea

Product 1

HCID 227605393-Ethyl-4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-1,3-thiazolidine-4-ol-hydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6.2 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone and 2.92 g of 1-ethyl-3-isopropylthiourea were heated in 40 ml of acetone for 15 minutes to 40° C, the mixture was stirred for another 30 minutes at room temperature and the crystals were filtered.

Workup

  1. filtrationthe crystals were filtered

Sources & evidence

ORD record
ord-a86e179a5d4c4cf3b5479c5b39579ddc
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Linked notes

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