Bromo-4'-chloro-3'-sulfamoylacetophenone → 4-(4-Chloro-3-sulfamoylphenyl)-2-isobutylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

HRID 461122

Reaction equation

HRID 461122 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][Br:10])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13].[CH2:16]([NH:20][C:21]([NH:23][CH3:24])=[S:22])[CH:17]([CH3:19])[CH3:18]>>[BrH:10].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:11])[CH2:9][S:22][C:21](=[N:20][CH2:16][CH:17]([CH3:19])[CH3:18])[N:23]2[CH3:24])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenoneHCID 155682431-Isobutyl-3-methylthiourea

Product 1

HCID 227604724-(4-Chloro-3-sulfamoylphenyl)-2-isobutylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

Procedure

6.2 g of 4'-chloro-3'-sulfamoyl-2-bromoacetophenone and 3.0 g of 1-isobutyl-3-methylthiourea were reacted according to the prescription made in Example 23 and the colorless end product was precipitated with 200 ml of diethyl ether.

Workup

  1. customthe colorless end product was precipitated with 200 ml of diethyl ether

Sources & evidence

ORD record
ord-3030b07c7e8244d4aca4cef3dee0274f
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Linked notes

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