Dicyclohexylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461134Notes

Reaction equation

HRID 461134 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:22][C:23]([NH:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:24][C:23](=[N:22][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[N:25]2[CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 727200DicyclohexylthioureaHCID 213167492,4'-Dichloro-3'-sulfamoylacetophenone

Product 1

HCID 227605234-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

Procedure

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 4.8 g of 1,3-dicyclohexylthiourea were reacted according to the prescription made in Example 12, the end product was precipitated with 200 ml of diethyl ether and the oil was crystallized after decanting the solvent with diethyl ether. Colorless, crystalline solid body: melting point: 177° C (from acrylonitrile).

Workup

  1. customthe end product was precipitated with 200 ml of diethyl ether
  2. customthe oil was crystallized
  3. customafter decanting the solvent with diethyl ether

Sources & evidence

ORD record
ord-0cba33b3992a44f6a9575dbd8486e604
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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