2-Chloro-4'-methyl-3'-sulfamoylacetophenone → 3-Hydroxy-3-(4-methyl-3-sulfamoylphenyl)-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-hydrochloride

HRID 461157

Reaction equation

HRID 461157 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[N:16]1[CH2:21][CH2:20][CH2:19][NH:18][C:17]=1[SH:22]>>[ClH:1].[OH:4][C:3]1([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)[N:18]2[CH2:19][CH2:20][CH2:21][N:16]=[C:17]2[S:22][CH2:2]1

Participants

3

Reactant 2

HCID 136287832-Chloro-4'-methyl-3'-sulfamoylacetophenoneHCID 178527864HCID 178527864, compound

Product 1

HCID 227605543-Hydroxy-3-(4-methyl-3-sulfamoylphenyl)-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-hydrochloride

Procedure

5 g of 2-chloro-4'-methyl-3'-sulfamoylacetophenone and 2.35 g of ground 3,4,5,6-tetrahydro-2-pyrimidine-thiol were reacted as prescribed in Example 12 and worked up as prescribed in Example 67d). Colorless crystals, melting point: 190° C (decomposition).

Sources & evidence

ORD record
ord-adfeee94392d456dabdd82142130dbdc
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Linked notes

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