Nitric Acid → 4-Isopropylnitrobenzene

HRID 461436

Reaction equation

HRID 461436 reaction equation
[C:1]1([CH:7]([CH3:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+:10]([O-])([OH:12])=[O:11].S(=O)(=O)(O)O>>[CH:7]([C:1]1[CH:6]=[CH:5][C:4]([N+:10]([O-:12])=[O:11])=[CH:3][CH:2]=1)([CH3:9])[CH3:8]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 7406Cumene

Product 1

HCID 157494-Isopropylnitrobenzene

Procedure

To 100 g. of cumene at 10° C. is slowly added over a period of 2.5hours to a mixture of 70.5 ml. of concentrated nitric acid and 109ml. of concentrated sulfuric acid. The reaction mixture is stirred at 5° to 10° C. for 1 hour following the addition. The reaction mixture is poured onto 250 ml. of ice water and extracted with ether. The ether is dried and evaporated in vacuo and the residue distilled at 9.5 to 10.5 mm./Hg. The fraction boiling at 130° C. is taken and used as is in the next step.

Workup

  1. additionthe addition
  2. additionThe reaction mixture is poured onto 250 ml
  3. extractionof ice water and extracted with ether
  4. dry with materialThe ether is dried
  5. customevaporated in vacuo
  6. distillationthe residue distilled at 9.5 to 10.5 mm

Sources & evidence

ORD record
ord-c7538f15d4ff47b1ae2610e31e7623fb
Source dataset
uspto-grants-1977_12
Patent number
US04062952

Linked notes

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