Cyclohexylamine → 2-(2-n-Octylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462240

Reaction equation

HRID 462240 reaction equation
[CH:1]1([NH:7][N:8]2[NH:12][CH:11]=[C:10]([C:13]3[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=3)[S:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:22](N)[CH2:23]CCCCCC.C1(N)CCCCC1>>[CH2:1]([NH:7][N:8]1[NH:12][CH:11]=[C:10]([C:13]2[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=2)[S:9]1)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:22][CH3:23]

Participants

4

Reactant 3

HCID 7965CyclohexylamineHCID 8143OctylamineHCID 213908612-(2-Cyclohexylamino-5-thiadiazolyl)-1-methyl-5nitroimidazole

Product 1

HCID 681202602-(2-n-Octylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Procedure

The preparation of the above compound is carried out essentially as described for the 2-cyclohexylamino derivative (Example 38), an equivalent of n-octylamine replacing the cyclohexylamine. The crude product is purified by recrystallization from aqueous 2-methoxyethanol and then melts at 130°-132° C.

Workup

  1. customThe preparation of the above compound
  2. customThe crude product is purified by recrystallization from aqueous 2-methoxyethanol

Sources & evidence

ORD record
ord-753b35837da44544a0a6e1d524189248
Source dataset
uspto-grants-1977_12
Patent number
US04065567

Linked notes

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