HCID 12595613, compound → HCID 12595637, compound

Reaction equation

C1O[C:4]2([CH2:9][CH2:8][C:7]([N:15]([CH3:17])[CH3:16])([C:10]3[S:11][CH:12]=[CH:13][CH:14]=3)[CH2:6][CH2:5]2)[O:3]C1.ClC1C=CC(C2(N(C)C)CCC(=O)CC2)=CC=1>>[CH3:16][N:15]([CH3:17])[C:7]1([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1

Participants

Reactant 2

HCID 12595613HCID 12595613, compound

HCID 125956504-(4-Chlorophenyl)-4-(dimethylamino)cyclohexan-1-one

Product 1

HCID 12595637HCID 12595637, compoundYield 64%

Procedure

Following the procedure of Example 2, but substituting the appropriate quantity of 4-dimethylamino-4-(2-thienyl)cyclohexanone ethylene ketal (prepared above in Example 27H) for the 4-(p-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal hydrochloride there is prepared (after recrystallization from methanol-water) the title compound in 64% yield, m.p. 102°-103° C.

Workup

customis prepared
custom(after recrystallization from methanol-water) the title compound in 64% yield, m.p. 102°-103° C.

Sources & evidence

ORD record: ord-c982d637273c4aab89fdd32d25ba4e05
Source dataset: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04065573

Reaction notes

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