HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 4-chloro-2-(4-hydroxyphenylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 4-Chloro-2-((4-methoxyphenyl)amino)benzoic acid | HCID 66674 | — |
| Reactant | 4-Chloro-2-(4-hydroxyphenylamino)benzoic acid | HCID 425423 | — |
| Reactant | HCID 20225134 | HCID 20225134 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-chloro-2-(4-hydroxyphenylamino)benzoic acid | HCID 20225128 | — |
Reaction Steps
[I; R=4-Cl, R' and R"=H, Alk=CH3, OH at 4-position] is obtainable by esterification of 4-chloro-2-(4-hydroxyphenylamino)benzoic acid with methanol and hydrochloric acid; or by esterification of 4-chloro-2-(4-methoxyphenylamino)benzoic acid with dimethyl sulfate, followed by de-etherification of the resulting methyl 4-chloro-2-(4-methoxyphenylamino)benzoate with boron tribromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04515980 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-a077546466954d6184495be609ecff98 |
| Source note | uspto-grants-1985_05 |