Aluminum Stearate → Xylometazoline
Reaction equation
C([O-])(=O)CCCCCCCCCCCCCCCCC.[Al+3].C([O-])(=O)CCCCCCCCCCCCCCCCC.C([O-])(=O)CCCCCCCCCCCCCCCCC.[CH3:62][C:63]1[CH:64]=[C:65]([C:76]([CH3:79])([CH3:78])[CH3:77])[CH:66]=[C:67]([CH3:75])[C:68]=1[CH2:69][C:70]1[NH:74][CH2:73][CH2:72][N:71]=1.Cl>>[CH3:75][C:67]1[CH:66]=[C:65]([C:76]([CH3:79])([CH3:78])[CH3:77])[CH:64]=[C:63]([CH3:62])[C:68]=1[CH2:69][C:70]1[NH:74][CH2:73][CH2:72][N:71]=1Participants
3
Conditions
- Temperature
- 115 °C
Procedure
The aluminium stearate was dispersed with stirring in a portion of the sunflower oil heated to 115° C. The dispersion was added to the rest of the sunflower oil heated to 140° C. The gel was stirred at 130° C. for 15 minutes and then allowed to cool without stirring to room temperature. The milled xylometazoline hydrochloride was dispersed in the cooled gel base and then passed through a colloid mill to produce a fine, homogenous dispersion. The dispersion was filled into plastic bottles fitted with a dosing pump.