HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 4'-Chloro-3-phenylpropiophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Benzenepropanoyl chloride | HCID 64801 | — |
| Reactant | HCID 178478191 | HCID 178478191 | — |
| Catalyst | Cadmium chloride, dihydrate | HCID 24633 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4'-Chloro-3-phenylpropiophenone | HCID 247344 | 58% |
Reaction Steps
Phenylpropionyl chloride (33.7 g) in benzene was added dropwise to a stirred mixture of 4-chlorophenyl magnesium bromide (derived from 38 g of 4-chlorobromobenzene) and cadmium chloride (37 g) in benzene at 0°. The mixture was stirred at room temperature for 6 hours and aqueous ammonium chloride solution then added. Ether extraction yielded p-chlorophenyl phenylethyl ketone (25 g) m.p. 78°-79°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04520007 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-61dbe1b7ada641c0b901f2e585d9aef7 |
| Source note | uspto-grants-1985_05 |